Virological and Immunological Response to Antiretroviral Treatment in HIV-Infected Patients  

Oleh:

Intansari, Umi S. ; Dewi, Yunika Puspa ; Juffrie, Mohammad ; Soesatyo, Marsetyawan H. N. E. ; Subronto, Yanri W. ; Mulyono, Budi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 01 (Nov. 2016), page 67-73.
Topik: HIV infection; ART; Virological Response; Immunological Response
Fulltext: I01 v23 n1 p67 kelik2017.pdf (497.2KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

HIV/AIDS remains a significant global challenge. ART has made significant contribution by reducing viral replication, reducing morbidity from opportunistic infection, and improves the life of person living with HIV/AIDS. However there is a very limited data related with virological and immunological response including T cell activation during ART in Indonesia. The purpose of this study were to know the virological and immunological response to ARV therapy in HIV patients pre and 6 months after ART initiation. The subjects in this observational prospective study were 44 ART naive-HIV infected adults patients in RSUP Dr. Sardjito, Yogyakarta and RSUP Dr. Karyadi Hospital, Semarang. Blood samples were collected in 6 mL volume EDTA- tube, before and 6 month after ART initiation to determine the CD4 T cell count, Viral Load (VL) and percentage of CD8+/38+ T cell. Viral load was significantly decreased 6 month after ARV initiation, parallel with the percentage of CD8+/38+, while CD4 T cell was increased (p<0.0001). There were 35 (79.5%) patients obtained optimally CD4 T cells recovery (>50 cell/µL) and 9 patients were sub-optimal, after 6 months of ART initiation. Viral load were decreased more than 1 log10 copy/mL in 93% patients. We found 13.6% patients had discordance response. The VL positively correlated with CD8+/38+ cell percentage (r=0.58, p<0.0001) and negatively correlated with CD4 T cell count (r=–0.470 (p<0.0001). Based on this study we concluded, most HIV patients obtained concordance virological and immunological response 6 month after ART initiation. There were 20.45% non- responder and discordance responder patients that need to be evaluated and treated intensively.

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