Diagnostic Values of Mycobacterium Tuberculosis 38 KDA Antigen in Urine and Serum of Childhood Tuberculosis  

Oleh:

Iskandar, Agustin ; Leliawaty ; Arthamin, Maimun Z. ; Olivianto, Ery

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 01 (Nov. 2016), page 42-49.
Topik: 38 KDA Antigen; MTB; Urine; Serum; Childhood TB
Fulltext: I01 v23 n1 p42 kelik2017.pdf (261.06KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Diagnosis TB in children is difficult because the clinical presentation is unspecific, the lung radiography is hard to interpret, and the sputum is hard to get. Detection of Mycobacterium tuberculosis antigen is one of the available choice for diagnosing TB. The serological methods is a better choice because it is more feasible and non-invasive. The 38 kDa antigen is an extracellular lipoprotein which has immunogen potention. The study aims to compare the diagnostic value of 38 kDa antigen of Mycobacterium tuberculosis between urine and serum of childhood tuberculosis. This study was a cross sectional study by using consecutively sampling methods. The study done on June 2013-June 2014. The subject of the study was 54 children with suspected TB. The level of 38 kDa antigen was measured by using ELISA method. The level of 38 kDa antigen in urine and serum of TB subject were higher than non TB. The mean (SD) of antigen 38 kDa Mtb in the urine was [0.25 (0.388)] vs [0.03 (0.011)] p=0.002, with AUC of 84.3%, By using cut off point 0.04 ng/mL the sensitivity of Mtb urine was 83% and specificity of 71.43%. While in the serum, the mean of 38 kDa Mtb antigen was [14.21 (13.335)] vs [4.189 (0.386)] p=0.263,with AUC (63.5%). By using cut off point 4.25 ng/mL, the sensitivity was 53.2% and specificity of 57.1%. 38 kDa Mtb antigen in the urine is better than those in the serum for diagnosing childhood TB.

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