Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women  

Oleh:

Liwei Chen ; Shanshan Li ; Chunyan He ; Yeyi Zhu ; Louis, Germaine M. Buck

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 39 no. 03 (Mar. 2016), page 469-471.
Topik: Gestational Diabetes Mellitus; GDM
Fulltext: D05 v39 n3 p469 kelik2017.pdf (619.58KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses’ Health Study II. RESULTS The adjusted risk ratios for GDM across the age at menarche categories (=11, 12, 13, and =14 years) were 1.34 (95% CI 1.14–1.58), 1.13 (0.97–1.31), 1.11 (0.95–1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI. CONCLUSIONS These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

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