Pharmaceutical Properties of Venom Toxins and Their Potential in Drug Discovery  

Oleh:

Kool, Jeroen

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 27 no. 01 (Jan. 2016), page 1-8.
Topik: Venom; Toxin; Drug Discovery; Peptide; Pharmaceutical Activity
Fulltext: I03 v27 n1 p1 kelik2017.pdf (582.24KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Traditional pipelines feeding drugs coming to the market are declining. This is one of the reasons why nowadays the previously abandoned natural extract drug discovery programs are slowly coming back. In this scenario, small molecular metabolites from plants and single cell marine or soil organisms are gaining interest in pharmaceutical research again. Animal venoms are another source for finding new biopharmaceutical lead molecules and research interest in discovering bioactive molecules from venoms is rising. Venoms comprise often highly selective and potent bioactive peptides and small proteins for receptors and enzymes that are valid drug targets. This work discusses drug discovery research on bioactive compounds in venoms and gives older and more recent examples of bioactive compounds found in venoms from different animals. Common pharmaceutical targets that different classes of venom toxins interact with and information on developmental stages of several medicinal venom peptides are also discussed.

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