Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives  

Oleh:

Kumar, Ravindra ; Panwar, Hament

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 26 no. 01 (Jan. 2015), page 1-10.
Topik: Bis-Phenylarylidinylthiadiazolidinone Cyclopropane; Anti-Microbial; Anti-Inflammatory; Analgesic; Ulcerogenic; Toxicity Studies
Fulltext: I03 v26 n1 p1 kelik2017.pdf (677.12KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In Medicinal chemistry, heterocyclic derivatives contributed the largest classical division of organic chemistry. Thiadiazole compounds have been known for many biological activities such as hypoglycemic, anticancer, anti-inflammatory, anti-asthmatic, antihypertensive etc. On this research, several 1,1-bis [2-{2-(5-(arylidene)imino-1,3,4-thiadiazol-2-yl) methyl amino}- 1,3,4-thiadiazo-5-yl] cyclopropane 5(a-h) have been synthesized from cyclopropane dicarboxylic acid comprising thiadiazole moieties. All the synthesized compounds have been characterized by elemental (C,H,N) and spectral (I.R., 1H- NMR, Mass) analysis. Furthermore, all synthesized compounds were screened for their antifungal, antimicrobial, anti-inflammatory, analgesic, ulcerogenic and toxic activities. The Compound 5f, 3-chlorophenyl substituted was found the most potent in antimicrobial spectrum against all the used microbes. On the other hand, compound 5g, 4-hydroxy-3-methoxy phenyl substituted was found the most potent in anti-inflammatory, analgesic, and ulcerogenic activities which further evaluated for lesser toxicity test.

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