Analisis King’s Score di Penyakit Hati Kronis Berdasarkan Fibroscan  

Oleh:

Wira ; Lopa, Amaliyah T. ; Samad, Ibrahim Abdul

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 163-167.
Topik: King’s Score; Chronic Liver Disease; Liver Fibrosis; Fibroscan; Penyakit Hati Kronis; Fibrosis Hati
Fulltext: I01 v22 n2 p163 kelik2017.pdf (191.87KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Chronic liver disease is a commonly found disease in Indonesia and remains a serious health problem. Chronic liver disease often progresses to hepatic cirrhosis or hepatoma initiated by fibrotic process in liver. Liver biopsy result is a gold standard in determining the liver fibrosis degree, but it has some limitations. King’s Score is a non-invasive method that uses routine laboratory predictors related to liver fibrosis. Therefore, it is necessary to know the diagnostic value of King’s Score in determining the fibrosis degree of liver chronic disease by using fibro scan as the gold standard in stead of biopsy. This study was a retrospective study with data collected from the medical records from the Medical Record Installation at the Dr. Wahidin Sudirohusodo General Hospital between January 2011 up to December 2013. The study results derived from 99 samples with Spearman correlation test showed a significant relationship between the King’s Score and fibrosis degree of chronic liver disease (p=0.000 and r=0.651). The analysis of the receiver operating characteristics (ROC) indicated that in mild and moderate fibrosis the AUC value was too weak, whereas in heavy fibrosis the AUC value was 0.860, which was statistically very strong with a cut-off value of 7.15 and with a 80.6% sensitivity, and a 75.0% specificity, Positive Predictive Value59.5%, Negative Predictive Value 89.5%. This meant that the King’s Score value of >7.15 could be used as a heavy fibrosis degree predictor in chronic liver patients. Further studies are needed to analyze the King’s Score based on chronic liver disease etiology and use a liver biopsy as the gold standard in determining the degree of liver fibrosis.

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