CD4+ dan CD8+ Interferon Gamma Tuberkulosis Paru Aktif dan Tuberkulosis Laten  

Oleh:

Tambunan, Betty Agustina ; Wiwin, John ; Nugraha, Jusak ; Soedarsono

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 137-140.
Topik: CD4+-IFN?; CD8+-IFN?; Active TB; Latent TB; TB Paru Aktif; TB Laten
Fulltext: I01 v22 n2 p137 kelik2017.pdf (176.43KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Tuberculosis (TB) is a global health problem. Immune response through CD4+ T cells and CD8+T cells is needed to produce Interferon gamma (IFN-?). IFN-gamma is a cytokine that can kill Mycobacterium tuberculosis. Not all individuals will lead to illness or active diseases. The aim of this study was to know the cellular immune response like IFN-gamma expression of T-CD4+ cells and CD8+ cells between active TB with latent TB. The design of the study was cross sectional obervational in a population suffering from active and latent TB. The subjects consisted of 11 (eleven) active TB patients and 10 (ten) latent TB patients from the Special Pulmonary Hospital and the Dr Soetomo Hospital, Surabaya. The examination of interferon gamma expression of CD4+ and CD8+ was by Flowcytometry method. These results were analyzed by Student t test or Mann-Whitney test. The mean CD4+ percentage of active TB (28.75%) was lower than the latent one (TB) (33.21%) but no significant difference (P value=0.114) was shown. The mean CD8+ percentage of active TB (30.46%) was higher than the latent one (TB) (28.87%) but no significant difference (P value=0.481) was found. The mean CD4+IFN-? percentage of active TB (2.51%) was higher than latent one (TB) (1.10%) and there was a significant difference (P value=0.014). The mean CD8+IFN-? percentage of active TB (2.91%) was lower than latent one (TB) (4.41%) and there was a significant difference (P value=0.006). Based on this study, it can be concluded that the mean CD4+IFN-? percentage of active TB was higher than latent TB and there was a significant difference. The mean of CD8+IFN-? percentage of latent TB was higher than the active one (TB). This suggested that CD8+ has a dominant part in latent TB and may be caused by the role of other cytokines, or genetics, nutrition, and body mass index factors.

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