Heart Fatty Acid Binding Protein sebagai Petanda Biologis Diagnosis Sindrom Koroner AkutHeart Fatty Acid Binding Protein sebagai Petanda Biologis Diagnosis Sindrom Koroner Akut  

Oleh:

Puspitawati, Ira ; Sudana, I Nyoman G ; Setyawati ; Sukorini, Usi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 127-132.
Topik: Heart-Fatty Acid-Binding Protein; Troponin I; Acute Coronary Syndromes; Biomarkers; Immunoturbidimetry Assay; Sindrom Koroner Akut; Petanda Biologis; Immunoturbidimetric Assay
Fulltext: I01 v22 n2 p127 kelik2017.pdf (324.25KB)

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Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Heart-Fatty Acid-Binding Protein (H-FABP) is a membrane-bound protein that facilitates transport of fatty acids from the blood into the heart. It is a low molecular weight cytoplasmic protein. Because of its small size and location, it is released rapidly into the blood following myocardial damage. The H-FABP levels rise as early as between 1-3 hours after the onset of Acute Coronary Syndrome, the peak situation between 6--8 hours, and returns to normal within 24 hours. The purpose of this study was to know the cut-off value of Heart Fatty Acid Binding Protein with a sensitivity of at least 90% in patients with acute coronary syndrome in the Dr. Sardjito Hospital Yogyakarta. The researchers undertook a cross sectional evaluation of 75 consecutive patients admitted with acute chest pain suggestive of acute coronary syndrome (ACS). The H-FABP was measured by using immunoturbidimetry assay methods. The receiver operating characteristic (ROC) analysis was calculated for the cut off point, sensitivity and specificity estimation. A total of 75 patients (59 in the ACS group and 16 in the control group) were included in this study, and the majority of the ACS group (64 [76.2%]) were male patients with AMI, 20 (26.7%) had an ST-elevation myocardial infarction and the rest (21 [28%]) had a non–ST-elevation myocardial infarction. The optimized cut-off obtained for h-FABP was 15 ng/mL, showing a sensitivity and specificity of the H-FABP assay for detecting ACS as 98.31 (95% CI 90 to 100) and 93.75% (95% CI 86 to 99), respectively. The areas under the receiver operator characteristic (ROC) curves to distinguish ACS from non-ACS were 0.983 (95% CI: 0.927– 0.999) for H-FABP. The optimized cut-off obtained for H-FABP was 15 ng/mL, showing a 98.31% sensitivity and 93.75% specificity for detecting ACS in the Dr. Sardjito Hospital Yogyakarta.

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