General Anesthetics and Neurotoxicity: How Much Do We Know?  

Oleh:

Jevtovic-Todorovic, Vesna

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Anesthesiology Clinics (keterangan: ada di ClinicalKey) vol. 34 no. 03 (Sep. 2016), page 439-451.
Topik: Learning and Memory; Immature Brain; Aging Brain; Synaptogenesis; GABA; NMDA; Synaptic Transmission
Fulltext: A34 v34 n3 p439 kelik2016.pdf (1.13MB)

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Perpustakaan FK Nomor Panggil: A34.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Over a decade ago, alarming findings were reported that exposure of the very young and very old animals to clinically used general anesthetics could be detrimental to their brains. The evidence presented suggested that the exposure to commonly used gaseous and intravenous general anesthetics induces the biochemical and morphologic changes in the immature and aging neurons ultimately resulting in their demise. More alarming was the demonstration of significant cognitive and behavioral impairments noted long after the initial anesthesia exposure. This article provides an overview of anesthesia-induced developmental neurotoxicity and commentary on the effects of general anesthesia on the aging brain.

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