Antimullerian Hormone: Correlation with Age and Androgenic and Metabolic Factors in Women from Birth to Postmenopause  

Oleh:

Linlin Cui ; Yingying Qin ; Xuan Gao ; Jun Lu ; Ling Geng ; Lingling Ding ; Zhongyu Qu ; Xiruo Zhang ; Zi-Jiang Chen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 105 no. 02 (Feb. 2016), page 481-485.
Topik: Age; AMH; Metabolism; Testosterone
Fulltext: F02 v105 n2 p481 kelik2016.pdf (423.72KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To study the age-specific distribution of antimüllerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages. Design: Cross-sectional study. Setting: University hospital. Patient(s): A total of 6,763 Chinese women from birth to menopause. Intervention(s): None. Main Outcome Measure(s): Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles. Result(s): According to the level of AMH, four age phases were established: childhood (0–10 years), adolescence (11–18 years), reproductive age (19–50 years), and advanced age (=51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = -0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase. Conclusion(s): From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.

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