Oral Glucose Tolerance Test Significantly Impacts the Prevalence of Abnormal Glucose Tolerance among Indian Women with Polycystic Ovary Syndrome: Lessons from a Large Database of Two Tertiary Care Centers on the Indian Subcontinent  

Oleh:

Ganie, Mohd Ashraf ; Dhingra, Atul ; Nisar, Sobia ; Sreenivas, Vishnubhatla ; Shah, Zaffar Amin ; Rashid, Aafia ; Masoodi, Shariq ; Gupta, Nandita

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 105 no. 01 (Jan. 2016), page 194-201.
Topik: PCOS; Diabetes Mellitus; Abnormal Glucose Tolerance; OGTT; Family History; IR; Hyperandrogenism
Fulltext: F02 v105 n1 p194 kelik2016.pdf (547.04KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To estimate the prevalence of abnormal glucose tolerance (AGT) among Indian women with polycystic ovary syndrome (PCOS) and analyze the role of oral glucose tolerance (OGTT) test on its estimation. Design: Cross-sectional clinical study. Setting: Tertiary care center. Patient(s): A total of 2,014 women with PCOS diagnosed on the basis of the Rotterdam 2003 criteria were enrolled, and the data of 1,746 subjects were analyzed. Intervention(s): In addition to recording clinical, biochemical, and hormone parameters, a 75 g OGTT was administered. Main Outcome Measure(s): Prevalence of AGT and impact of age, body mass index (BMI), family history, and OGTT on its prevalence. Result(s): The mean age of subjects was 23.8 ± 5.3 years, with a mean BMI of 24.9 ± 4.4 kg/m2. The overall prevalence of AGT was 36.3% (6.3% diabetes and 30% impaired fasting plasma glucose/impaired glucose tolerance) using American Diabetes Association criteria. The glucose intolerance showed a rising trend with advancing age (30.3%, 35.4%, 51%, and 58.8% in the second, third, fourth, and fifth decades, respectively) and increasing BMI. Family history of diabetes mellitus was present in 54.6% (953/1,746) subjects, and it did not correlate with any of the studied parameters except waist circumference and BMI. Sensitivity was better with 2-hour post-OGTT glucose values as compared with fasting plasma glucose, since using fasting plasma glucose alone would have missed the diagnosis in 107 (6.1%) subjects. Conclusion(s): We conclude that AGT is high among young Indian women with PCOS and that it is not predicted by family history of type 2 DM. OGTT significantly improves the detection rate of AGT among Indian women with PCOS.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali