Acetosal Resistance in Coronary Artery Disease Between and Within Type 2 Diabetes Mellitus Patients  

Oleh:

K, Ari Yunita ; Suharjono ; Yogiarto, Mohammad ; SZ, Bambang

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Folia Medica Indonesiana vol. 51 no. 2 (2015), page 137-141.
Topik: Asetosal Resistance; Type 2 Diabetes Mellitus; Coronary Artery Disease
Fulltext: download-fullpapers-fmi42e920eebdfull.pdf (80.31KB)

Isi artikel

Acetosal reduces the odds of an arterial thrombotic event in high risk patients. However, 10%-20% of patients with an arterial thrombotic event who are treated with acetosal have a recurrent arterial thrombotic event during long-term follow up. Acetosal resistance has been described in some patient populations such as those with an acute coronary syndrome, ischemic stroke, and percutaneous coronary intervention with drug-eluting stent, stent re-stenosis, and Type 2 Diabetes Mellitus. Patients were divided into two groups of ten patients each, 10 patients Coronary Artery Diseases with Type 2 Diabetes Mellitus and 10 patients non-Type 2 Diabetes Mellitus. The sampling of this cross sectional study was conducted at departement of Cardiology Dr. Soetomo Hospital Surabaya during July-August 2014. Data from 20 patients were analyzed after exclusion due to protocol violations. All subjects were on Asetosal 100 mg/day. Four (40%) patients with Type 2 Diabetes Mellitus were acetosal non-responders, acetosal resistance was observed in 3 (30%) of nondiabetic patients (p=1.000). In conclusion, no difference has been found on acetosal resistance in coronary artery disease patients with or without Type 2 Diabetes Mellitus. (FMI 2015;51:137-141)

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