Relationship between Sperm Aneuploidy, Sperm DNA Integrity, Chromatin Packaging, Traditional Semen Parameters, and Recurrent Pregnancy Loss  

Oleh:

Zidi-Jrah, Ines ; Hajlaoui, Amani ; Mougou-Zerelli, Soumaya ; Kammoun, Molka ; Meniaoui, Imene ; Sallem, Amira ; Brahem, Sonia ; Fekih, Meriem ; Bibi, Mohammed ; Saad, Ali ; Ibala-Romdhane, Samira

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 105 no. 01 (Jan. 2016), page 58-64.
Topik: Spermatozoa; Pregnancy Loss; DNA Damage; Aneuploidy
Fulltext: F02 v105 n1 p58 kelik2016.pdf (222.99KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To study the possible relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters, and recurrent pregnancy loss (RPL). Design: Descriptive study. Setting: University-affiliated tertiary teaching. Patient(s): A total of 22 couples with history of RPL and 20 fertile men. Intervention(s): Semen samples from case and control men were examined for differences in semen parameters, DNA fragmentation, chromatin condensation, and sperm aneuploidy. Main Outcome Measure(s): Sperm DNA and chromatin integrity and sperm aneuploidy. Result(s): Sperm progressive motility (30.2% vs. 51.5%) was significantly lower and abnormal morphology (74.8% vs. 54.2%) was significantly higher in the RPL group versus the control group, respectively. The percentage of fragmented DNA was significantly increased in the RPL group (17.1% vs. 10.2%) as well as the rate of spermatozoa with nuclear chromatin decondensation (23.6% vs. 11.8%). There was a significantly higher sperm aneuploidy rate among the RPL group as well. Conclusion(s): The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL

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