Pro-permeability Factors in Diabetic Macular Edema; the Diabetic Macular Edema Treated With Ozurdex Trial  

Oleh:

Campochiaro, Peter A. ; Hafiz, Gulnar ; Mir, Tahreem A. ; Scott, Adrienne W. ; Zimmer-Galler, Ingrid ; Shah, Syed M. ; Wenick, Adam S. ; Brady, Christopher J. ; Han, Ian ; Lingmin He ; Channa, Roomasa ; Poon, David ; Meyerle, Catherine ; Aronow, Mary Beth ; Sodhi, Akrit ; Handa, James T. ; Kherani, Saleema ; Yong Han ; Sophie, Raafay ; Guohua Wang ; Jiang Qian

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American Journal of Ophthalmology (keterangan: ada di ClinicalKey) vol. 168 (Aug. 2016), page 13-23.
Topik: Diabetic Macular Edema; DME
Fulltext: A12 v168 p13 kelik2016.pdf (3.86MB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Purpose: The Diabetic Macular Edema Treated with Ozurdex (DMEO) Trial measured aqueous pro-permeability factors (PPFs) in diabetic macular edema (DME) patients before and after injection of dexamethasone implant or vascular endothelial growth factor (VEGF)-neutralizing protein and correlated changes in levels with changes in excess foveal thickness (EFT) to identify potential PPFs contributing to DME. Design: Prospective, randomized crossover clinical trial. Methods: Twenty DME patients randomized to dexamethasone implant or VEGF-neutralizing protein had aqueous taps and spectral-domain optical coherence tomography (SDOCT) at baseline and every 4 weeks for 28 weeks. Aqueous levels of 55 vasoactive proteins were measured with protein array. Crossover at week 16 provided changes in protein levels after each intervention in all 20 patients. Results: After dexamethasone implant there was significant correlation between changes in levels of 13 vasoactive proteins with changes in EFT, including 3 known PPFs: angiopoietin-2 (r = 0.40, P = .001), hepatocyte growth factor (HGF; r = 0.31, P = .02), and endocrine gland-VEGF (EG-VEGF, r = 0.43, P < .001). Reduction of prolactin, insulin-like growth factor binding protein-3, and matrix metalloproteinase-9 correlated with edema reduction after injection of a VEGF-neutralizing protein as well as dexamethasone implant, suggesting their modulation is likely secondary to changes in edema rather than causative. Conclusions: Correlation of edema reduction with reduction in the PPFs angiopoietin-2, HGF, and EG-VEGF provides potential insight into the multifactorial molecular mechanism by which dexamethasone implants reduce edema and suggest that additional study is needed to investigate the contributions of these 3 factors to chronic DME.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali