Chlamydia Trachomatis Immunoglobulin G3 Seropositivity is a Predictor of Reproductive Outcomes in Infertile Women with Patent Fallopian Tubes  

Oleh:

Steiner, Anne Z. ; Diamond, Michael P. ; Legro, Richard S. ; Schlaff, William D. ; Barnhart, Kurt T. ; Casson, Peter R. ; Christman, Gregory M. ; Alvero, Ruben ; Hansen, Karl R. ; Geisler, William M. ; Thomas, Tracey ; Santoro, Nanette ; Heping Zhang ; Eisenberg, Esther

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 06 (Dec. 2015), page 1522–1526.
Topik: Chlamydia Trachomatis; Infertility; Pregnancy; Ectopic Pregnancy
Fulltext: F02 v104 n6 p1522 kelik2016.pdf (195.11KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To determine if Chlamydia trachomatis (C. trachomatis) seropositivity, as detected by the C. trachomatiselementary body (EB)–based enzyme-linked immunosorbent assay [EB ELISA] predicts pregnancy and pregnancy outcome among infertile women with documented tubal patency. Design: Cohort study. Setting: Outpatient clinics. Patient(s) In all, 1,250 infertile women with documented tubal patency enrolled in 1 of 2 randomized controlled trials: Pregnancy in Polycystic Ovary Syndrome II; and the Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Intervention(s) Sera were analyzed for anti–C. trachomatis immunoglobulin G (IgG)1 and IgG3 antibodies, using a researchC. trachomatis EB ELISA. The optical density (OD)405 readings of =0.35 and =0.1 were considered positive for IgG1 and IgG3, respectively. Main Outcome Measure(s) Primary outcomes included pregnancy, live birth, and ectopic pregnancy. Log-linear regression was used to determine the relative risk after adjusting for age, race, treatment medication, smoking status, and current alcohol use. Result(s) A total of 243 (19%) women were seropositive for anti–C. trachomatis IgG3. They tended to be nonwhite and smokers. Anti–C. trachomatis IgG3 seropositive women were significantly less likely to conceive (risk ratio [RR] 0.65, 95% confidence interval [CI] 0.52–0.83) or to have a live birth (RR 0.59, 95% CI 0.43–0.80); these associations were weakened after adjusting for number of hysterosalpingography-documented patent tubes (RR 0.73, 95% CI 0.56–0.97) and (RR 0.73, 95% CI 0.50–1.04), respectively. Anti–C. trachomatis IgG3 seropositive women who conceived had a ×2.7 risk (95% CI 1.40–5.34) of ectopic pregnancy. Conclusion(s) Even in the presence of tubal patency, anti–C. trachomatis IgG3 seropositivity is associated with a lower likelihood of pregnancy. Anti–C. trachomatis IgG3 seropositive women have as high as 3 times the risk of ectopic pregnancy.

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