Long-Term Follow-Up of Patients with an Isolated Ovarian Recurrence After Conservative Treatment of Epithelial Ovarian Cancer: Review of the Results of an International Multicenter Study Comprising 545 Patients  

Oleh:

Bentivegna, Enrica ; Fruscio, Robert ; Roussin, Stephanie ; Ceppi, Lorenzo ; Satoh, Toyomi ; Kajiyama, Hiroaki ; Uzan, Catherine ; Colombo, Nicoletta ; Gouy, Sebastien ; Morice, Philippe

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 05 (Nov. 2015), page 1319–1324.
Topik: Conservative Surgery; Epithelial Ovarian Tumor; Extraovarian Recurrence; Prognosis; Recurrence
Fulltext: F02 v104 n5 p1319 kelik2016.pdf (197.67KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To determine the long-term outcomes of patients with an isolated ovarian recurrence after fertility sparing surgery (FSS) for epithelial ovarian cancer (EOC) and to evaluate the recurrence rates (and location) according to the new 2014 International Federation of Gynecology and Obstetrics (FIGO) staging system. Design: Retrospective multicenter study. Setting: Teams having reported recurrence after FSS for EOC. Patient(s): Four series comprising 545 patients undergoing FSS and 63 (12%) recurrences. Intervention(s): FSS (salpingo-oophorectomy for a majority of cases) for EOC. Main Outcomes Measure(s): Recurrences rates and characteristics of recurrent disease. Result(s): Among 63 recurrent patients, 24 (38%) recurrences were isolated on the spared ovary, and 39 (62%) arose at an extraovarian site. Among the patients with an isolated ovarian recurrence, three patients died after a median follow-up period of 186 months (range: 28–294 months). Among the patients with recurrent extraovarian disease, 24 died and 7 were alive with persistent disease after a median follow-up period of 34 months (range: 3–231 months). The overall rate of isolated ovarian and extrapelvic recurrences was higher for grade 3 tumors (compared with grades 1/2). Conclusion(s): The long-term survival of patients with an isolated ovarian recurrence after FSS for EOC remains favorable. The prognosis of patients with an extraovarian recurrence is poor compared with those who have an isolated recurrent ovarian tumor. Grade 3 tumors (compared to grades 1/2) give rise to a higher rate of extraovarian recurrences.

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