Presence of Human Papillomavirus in Semen of Healthy Men Is Firmly Associated with HPV Infections of the Penile Epithelium  

Oleh:

Luttmer, Roosmarijn ; Dijkstra, Maaike G. ; Snijders, Peter J. F. ; Jordanova, Ekaterina S. ; King, Audrey J. ; Garolla, Andrea ; Hompes, Peter G. ; Berkhof, Johannes ; Bleeker, Maaike C. G. ; Doorbar, John ; Heideman, Danielle A. M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 04 (Oct. 2015), page 838–844.
Topik: Flat Penile Lesion; Human Papillomavirus; Semen; Transmission
Fulltext: F02 v104 n4 p838 kelik2016.pdf (1.11MB)

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Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Objective: To study the source of human papillomavirus (HPV) in semen. Design: Observational study (CCMO-NL3248800010). Setting: Academic hospital-based laboratory. Patient(s): Healthy male volunteers (n = 213). Intervention(s): One penile scrape and three semen samples were obtained per participant for HPV-DNA testing by both GP5+/6+ polymerase chain reaction (PCR) and SPF10-PCR to detect moderate/high and low viral loads, respectively; flat penile lesions (FPL) were detected by penoscopy. Main Outcome Measure(s): HPV-DNA presence in semen and penile scrapes, and the presence of FPL. Result(s): HPV-DNA at moderate/high viral loads (i.e., GP5+/6+ PCR-positive) was detected in =1 semen sample(s) in 27% of participants. Most men with moderate/high viral loads in the penile scrape also had moderate/high viral loads in semen (85%). Men with a HPV-negative penile scrape were very unlikely to have moderate/high viral loads in semen (3%). The presence of HPV in semen was associated with the presence of HPV in the penile scrape also on a genotype-specific level. Having FPL was a risk factor for HPV presence in semen. Conclusion(s): HPV-DNA presence in semen of healthy men is common and associated with HPV infections of the penile epithelium. HPV-DNA presence in semen may result from desquamation of HPV-infected penile cells.

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