Are Good Patient and Embryo Characteristics Protective Against the Negative Effect of Elevated Progesterone Level on the Day of Oocyte Maturation?  

Oleh:

Hill, Micah J. ; Royster IV, Greene Donald ; Mae Wu Healy ; Richter, Kevin S. ; Levy, Gary ; DeCherney, Alan H. ; Levens, Eric D. ; Suthar, Geeta ; Widra, Eric ; Levy, Michael J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 06 (Jun. 2015), page 1477–1484.
Topik: Elevated Progesterone; Premature Luteinization; Implantation; IVF
Fulltext: F02 v103 n6 p1477 kelik2016.pdf (1.84MB)

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Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To evaluate if an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration is associated with a decrease in live-birth rate in patients with a good prognosis. Design: Retrospective cohort study. Setting: Large, private, assisted reproductive technology (ART) practice. Patient(s): One thousand six hundred twenty fresh autologous ART cycles. Intervention(s): None. Main Outcome Measure(s): Live-birth rate. Result(s): A total of 934 blastocyst and 686 cleavage-stage embryo transfer (ET) cycles were evaluated. Serum P levels were not associated with markers of oocyte or embryo quality, including fertilization, embryo stage at transfer, and embryos available for cryopreservation. Patient age, stage of ET, embryo quality, the number of embryos transferred, and P level on the day of hCG administration were all significantly associated with live birth. Higher P levels were associated with decreased odds of live birth for cleavage- and blastocyst-stage embryos, poor-fair and good-quality embryos, and poor- and high-responder patients. The nonsignificance of interaction tests of P levels with embryo stage, embryo quality, patient age, and ovarian response indicated that the relationship between P level and live birth was similar regardless of these factors. Conclusion(s): An elevated serum P level on the day of hCG administration was negatively associated with live birth, even in ETs with a good prognosis. (Fertil Steril_ 2015;103:1477–84. _2015 by American Society for Reproductive Medicine.)

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