Adverse Pregnancy and Birth Outcomes Associated with Underlying Diagnosis with and without Assisted Reproductive Technology Treatment  

Oleh:

Stern, Judy E. ; Luke, Barbara ; Tobias, Michael ; Gopal, Daksha ; Hornstein, Mark D. ; Diop, Hafsatou

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 06 (Jun. 2015), page 1438–1445.
Topik: ART; Endometriosis; Ovulatory Disorder; Pregnancy Outcome; Preterm Delivery; Low Birth Weight
Fulltext: F02 v103 n6 p1438 kelik2016.pdf (207.29KB)

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Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without assisted reproductive technology (ART) treatment to non-ART pregnancies in fertile women. Design: Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting: Not applicable. Patient(s): Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospitaldischarges in women who had ART treatment (n ¼ 3,689), women with no ART treatment in the current pregnancy (n ¼ 4,098), and non-ART pregnancies in fertile women (n ¼ 297,987). Intervention(s): None. Main Outcome Measure(s): Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age weremodeled usingmultivariate logistic regressionwith fertile deliveries as the reference group adjusted formaternal age, race/ethnicity, education, chronic hypertension, diabetesmellitus, and plurality (adjusted odds ratios [AORs] and 95%confidence intervals [CIs]). Result(s): Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s): The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women. (Fertil Steril_ 2015;103:1438–45. _2015 by American Society for Reproductive Medicine.)

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