Neighborhood X Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children  

Oleh:

Windle, Michael ; Brody, Gene H. ; Kogan, Steven M. ; Beach, Steven R. H. ; Lee, Sunbok ; Yu, Tianyi ; Chen, Yi-Fu ; Lei, Karlo Mankit

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 28 no. 2 (May 2016), page 415-431.
Topik: Neighborhood and 5-HTTLPR interactions for substance use
Fulltext: 415 - 431_her.pdf (343.49KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate GeneEnvironment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test GeneEnvironment interactions for an under studied sample.

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