The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence  

Oleh:

Musci, Rashelle J. ; Ialongo, Nicholas S. ; Masyn, Katherine E. ; Benke, Kelly ; Maher, Brion ; Uhl, George

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 28 no. 1 (Feb. 2016), page 225-237.
Topik: Interplay of genetics and environmental risk
Fulltext: 225-237_her.pdf (312.92KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore GeneEnvironment interactions found in internalizing symptoms during adolescence. Data for this study were drawn froma longitudinal prevention intervention study (n ¼798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A GeneEnvironment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence.

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