Predicting childhood effortful control from interactions between early parenting quality and children’s dopamine transporter gene haplotypes  

Oleh:

Li, Yi ; Sulik, Michael J ; Eisenberg, Nancy ; Spinrad, Tracy L. ; Lemery-Chalfant, Kathryn ; Stover, Daryn A ; Verrelli, Brian C

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 28 no. 1 (Feb. 2016), page 199-212.
Topik: Predicting childhood effortful control
Fulltext: 199-212_her.pdf (300.33KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Children’s observed effortful control (EC) at 30, 42, and 54 months (n ¼ 145) was predicted from the interaction between mothers’ observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3 0 -untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3 0 -UTR VNTR-10, or intron13-G/3 -UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis–stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children’s sensitivity/responsivity to early parenting.

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