Mieloma Multipel Nonsecretory  

Oleh:

Arthamin, Maimun Zulhaidah ; Wahidah, Nyi R ; Sihite, Boy A

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 01 (Nov. 2015), page 99-103.
Topik: Mieloma Multipel Nonsecretory; Jejas Osteolitik; Protein M Negatif

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The incidence of non-secretory multiple myeloma ranged between 1-5% cases of plasma cell dyscrasia (PCD). In the developed countries like in Europe, cases of MM ranged from 4.5 up to 6.0/100.000 population/year with a median age at diagnosis between 63 and 70 years. A very rare disease with difficulties in diagnosis in the clinical practice is the main reason for reporting this case. A nonsecretory MM (MMNS) case was reported in a 36–year-old male with multiple osteolytic lesions and bone pain; whereas renal insufficiency as well as anemia was not found. The protein electrophoresis result showed a presence of hypoglobulinemia. On bone marrow aspiration (BMA) there was an infiltration of about 40% of plasma cells. Nonsecretory was due to a disruption of immunoglobulin secretion, so M protein was not found in immuno-fixation electrophoresis. Epidemiological data showed that the incidence of MM in young age is very low. The diagnosis of MMNS is established when a plasmocyte neoplasm is not accompanied by renal insufficiency, hypercalcemia and decreased levels of normal immunoglobulin.

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