Fungsi dan Pemeriksaan Limfosit yqT  

Oleh:

Indrasari, Yulia Nandar ; Nugraha, Jusak

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 01 (Nov. 2015), page 92-98.
Topik: Limfosit T Gamma Delta; Sel Imun Alamiah; Sitokin

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

T lymphocytes most have TCR a and ß chains. However, TCR formed from ? and d chains determine a new subset of T lymphocytes. ?d TCR specific to different types of ligands, including bacterial phosphoantigen, nonclassical MHC-I molecules and unprocessed protein. ?d T lymphocytes have several innate cell-like features that allow their early activation following the recognition of conserved stress-induced ligands. ?d T lymphocytes able to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. They are capable of generating more unique antigen receptors than ?d T lymphocytes and B lymphocytes combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effectors functions have been ascribed to them, yet their biological functions remain unclear. Innate features of ?d T lymphocytes underlie their non-redundant role in several physiopathological contexts and are therefore being exploited in the design of new immunotherapeutic approaches. The purpose of writing is giving an overview in mainly functions of ?d T lymphocytes in the immune system and laboratory tests that expand knowledge about the introduction of ?d T lymphocytes.

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