Nitrit Oksida dan Volume Edema Otak pada Strok Perdarahan Dalam Otak dengan Polimorfisme G894T  

Oleh:

Zakaria, Iskandar ; Faisal, Arif ; Sadewa, Ahmad Hamim ; Imran

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 01 (Nov. 2015), page 87-91.
Topik: Polimorfisme Gen eNOS; Nitrit Oksida; Edema Perifokal; Strok Pendrahan Dalam Otak

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Nitric Oxide (NO) is a vasodilator that regulates vascular smooth muscle tone. Low levels of NO can cause vasoconstriction and hemodynamic disturbances. In stroke the levels of NO are increased. Endothelial nitric oxide synthase gene polymorphism (eNOS) is believed to reduce levels of NO in blood. NO levels decreased in stroke patients with G894T polymorphisms of eNOS gene. Mortality rate of hemorrhagic stroke are increased in case with increased peri focal edema volume. The mechanism of the increased of peri focal edema volume completely unknown yet, suspected genetics factor. This study was conducted to know the correlation between the NO and peri focal edema volume in stroke with eNOS gene G894T polymorphism by determination. The study was conducted by comparing the levels of NO and edema volume of intra cerebral hemorrhagic stroke of 46 subjects from Neurology department of dr. Zainoel Abidin general hospital in Banda Aceh from September 2014 through January 2015 with comparison to ischemic stroke patients the same amount. NO levels checked with Cayman Systems kit following the protocol Griess. G894T polymorphism was determined by PCR-RFLP method. The volume of edema was measured with semi-automatic CT volumetry. Chi Square test was used for comparison of two variables and Spearman correlation test to assess the relationship between the NO and perifocal edema volume. The result is significant, if p value was <0.05. The results of these study were levels of NO decreases if there were polymorphism (p=0.001). Peri focal edema volume was increased if there were G894T polymorphism (p=0.038). The correlation between low levels of NO and increase of edema volume was obtained p=0.040 and R=0.304. The researchers concluded that in intra cerebral hemorrhagic stroke the level of NO were decreased and peri focal edema volume increased if there was G894T polymorphism of eNOS gene. There was a less correlation between low levels of NO and peri focal edema volume.

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