Analisis Feritin dan AST to Platelet Ratio Indeks Sebagai Pertanda Derajat Fibrosis Penyakit Hati Kronis  

Oleh:

Yasin, yulianti ; Bahrun, Uleng ; Samad, Ibrahim Abdul

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 01 (Nov. 2015), page 72-76.
Topik: Feritin; AST to Platelet Ratio Index; Fibrosis Hati; Penyakit Hati Kronis

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Chronic liver disease is an endemic disease in Indonesia which is still a global health problem and detected when it’s developing into fibrosis. The determination of fibrosis is important for the treatment and prognosis of chronic liver disease. AST to Platelet Ratio Index (APRI) score is the most common used to assess the degree of liver fibrosis. Ferritin is an iron deposit that found in the liver and the levels depend on the degree of the cell damage. The aim of this study was to analyze ferritin levels as a marker of the fibrosis degree in the chronic liver disease. This cross-sectional study of 47 patients with chronic liver disease performed at Dr. Wahidin Sudirohusodo General Hospital between May–June 2012. The subjects are grouped into cirrhotic and noncirrhotic, based on the theory that in cirrhotic liver fibrosis was considered as an irreversible condition. AST to platelet ratio index score based on the Wai CT formulation, including the examination of AST by optimizing UV-test according to International Federation of Clinical Chemistry (IFCC) modified method on the ABX Pentra 400, examination of platelet by impedance method on Sysmex XT 2000i and ferritin levels were measured by ECLIA method using Elecsys 2010 Analyzer. The Spearman correlation tests showed no association between ferritin levels and APRI in cirrhotic and non cirrhotic patients (p=0.704 and r=–0.057). In conclusion, ferritin can not be used as the marker in determining the degree of fibrosis patients suffering chronic liver disease. Further studies are expected using a more valid method for determining the degree of fibrosis such as liver biopsy or fibro scan.

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