FCyII (CD32) Monosit di Infeksi Dengue Primer dan Sekunder  

Oleh:

Intansari, Umi S. ; Sukorini, Usi ; Sari, Shanti Ika

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 01 (Nov. 2015), page 42-47.
Topik: Infeksi Dengue Primer; Infeksi Dengue Sekunder; FcyIIR (CD32) Monosit; Flowcytometry

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Dengue infection is a major health problem in the world, including Indonesia. Clinical manifestations of dengue infection vary widely, from asymptomatic until dengue shock syndrome (DSS). Antibody Dependent Enhancement (ADE) hypothesis that states that non-neutralizing antibodies in secondary dengue infection may enhance dengue infection via Fc? receptors is still controversial. Clinical research shows that not all secondary infections manifest as DHF/DSS, but nearly all DHF/DSS cases are caused by secondary infection. Allegedly, the expression of Fc? has an effect on this incident. This study is an observational analytical study with a cross sectional design to determine the expression of Fc?RII (CD32) monocytes in patients with primary and secondary dengue infection. CD32 of monocytes was measured using FACS Calibur with lyse no wash technique. Primary and secondary dengue infection were determined by IgM/IgG optical density ratio using ELISA capture method. The ratio of IgM/IgG =1.2 was considered as primary infection, while the ratio <1.2 was considered as secondary infection. Twenty primary and 32 secondary dengue infection patients in acute phase of dengue infection partisipated in this study. Expressions of Fc? RII (CD32) monocytes were significantly lower in primary than secondary dengue i

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali