The Path to Cancer — Three Strikes and You're Out  

Oleh:

Vogelstein, Bert ; Kinzler, Kenneth W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 373 no. 20 (Nov. 2015), page 1895-1898.

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Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Nearly 30 years ago, it was hypothesized that cancers result from sequential mutations in specific oncogenes and tumor-suppressor genes.1 This hypothesis was based on experimental data from patients with colorectal cancers and inspired by models proposed by Armitage and Doll, Nowell, Knudson, and others. Those experimental data were rudimentary by today's standards. The sequence of all coding genes has now been determined for more than 22,000 cancers, and more than 3 million somatic mutations have been discovered. So has the sequential cancer gene hypothesis stood the test of time?

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