Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge  

Oleh:

Loyola, Adriano Mota ; Cardoso, Sergio Vitorino ; Faria, Paulo Rogerio de ; Servato, Joao Paulo Silva ; Amaral, Eisenberg, Ana Lucia

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 120 no. 03 (Sep. 2015), page 368–377 .

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma. Study Design Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19). Results There were 3 males (60%) and 2 (40%) females. The mean age was 44 ± 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67–positive cells were 72.4 ± 24.9 positive cells per high-power field (range 53-111). Conclusions To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.

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