Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)  

Oleh:

Sianturi, Julinton ; Purnamasari, Mayshah ; Mayanti, Tri ; Harneti, Desi ; Supratman, Unang ; Awang, Khalijah ; Hayashi, Hideo

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Sains vol. 19 no. 1 (Mar. 2015), page 7 - 12.
Topik: Aglaia eximia; cytotoxic activity; flavonoid compound; Meliaceae
Fulltext: 4476-8305-2-PB_ros.pdf (100.0KB)

Isi artikel

Three flavonoid compounds, kaempferol (1), kaempferol-3-O-a-L-rhamnoside (2), and kaempferol-3-O-ß-D-glucosyla-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR ( 1 H, 13 C, DEPT 135°, HMQC, HMBC, HCOSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC 50 values of 1.22, 42.92, and >100 mg/mL, respectively. 1 H- 1

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