Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.  

Oleh:

Wulansari, Dewi ; Jamal, Yuliasri ; Praptiwi ; Agusta, Andria

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Hayati Journal of Biosciences vol. 21 no. 02 (Jun. 2014), page 95-100.
Topik: Arcangelesia flava; endophytic fungi; Coelomycetes AFKR-18; pachybasin; antimicrobial activity
Fulltext: 8179-23064-2-PB_Ros.pdf (974.55KB)

Isi artikel

Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid medium. The chemical structure of pachybasin was deduced from MS, 1D-, 2D-NMR spectrum analysis, and from reference data. On a micro-dilution test, pachybasin showed antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 µg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 µg/mL respectively.

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