Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes  

Oleh:

Bae, Sajin ; West, Allyson A. ; Jian, Yan ; Xinyin, Jiang ; Perry, Cydne A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 145 no. 07 (Jul. 2015), page 1507-1514 .
Topik: vitamin B-12 pregnancy lactation holotranscobalamin homocysteine methylmalonic acid controlled feeding study reproductive state women of reproductive age

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Limited data are available from controlled studies on biomarkers of maternal vitamin B-12 status. Objective: We sought to quantify the effects of pregnancy and lactation on the vitamin B-12 status response to a known and highly controlled vitamin B-12 intake. Methods: As part of a 10–12 wk feeding trial, pregnant (26–29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant, nonlactating; n = 21) women consumed vitamin B-12 amounts of ~8.6 µg/d [mixed diet (~6 µg/d) plus a prenatal multivitamin supplement (2.6 µg/d)]. Serum vitamin B-12, holotranscobalamin (bioactive form of vitamin B-12), methylmalonic acid (MMA), and homocysteine were measured at baseline and study-end. Results: All participants achieved adequate vitamin B-12 status in response to the study dose. Compared with control women, pregnant women had lower serum vitamin B-12 (-21%; P = 0.02) at study-end, whereas lactating women had higher (P = 0.04) serum vitamin B-12 throughout the study (+26% at study-end). Consumption of the study vitamin B-12 dose increased serum holotranscobalamin in all reproductive groups (+16–42%; P = 0.009). At study-end, pregnant (vs. control) women had a higher holotranscobalamin–to–vitamin B-12 ratio (P = 0.04) with ~30% (vs. 20%) of total vitamin B-12 in the bioactive form. Serum MMA increased during pregnancy (+50%; P < 0.001) but did not differ by reproductive state at study-end. Serum homocysteine increased in pregnant women (+15%; P = 0.009) but decreased in control and lactating women (-16–17%; P < 0.001). Despite these changes, pregnant women had ~20% lower serum homocysteine than the other 2 groups at study-end (P = 0.02). Conclusion: Pregnancy and lactation alter vitamin B-12 status in a manner consistent with enhanced vitamin B-12 supply to the child. Consumption of the study vitamin B-12 dose (~3 times the RDA) increased the bioactive form of vitamin B-12, suggesting that women in these reproductive states may benefit from vitamin B-12 intakes exceeding current recommendations

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali