Immunohistochemical expression of cytokeratins in human salivary gland acinic cell carcinomas  

Oleh:

Xiaojie, Li ; Zheng, Shi ; Yuancai, Wang ; Yang, Liu ; Tingjiao, Liu

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 120 no. 02 (Aug. 2015), page 248–257 .

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare the expression of cytokeratins (CKs) in the solid, microcystic, follicular, and papillary–cystic subtypes of salivary gland acinic cell carcinoma (AcCC) in order to characterize the cell origin. Study Design The expression of CK7, CK14, CK19, CK20, and alpha–smooth muscle actin (a-SMA) in 18 cases of AcCC was assessed with the use of immunohistochemical staining. Ten normal salivary glands were used as controls. Results The expression of CKs in AcCCs varied according to their growth patterns. CK7 showed strong and diffuse positive staining in the microcystic, follicular, and papillary–cystic subtypes, whereas staining was weakly positive or negative in the solid subtype. CK14 expression was negative in almost all AcCCs. Expression of CK19 was observed in the microcystic, follicular, and papillary–cystic subtypes, but was minimally observed in the solid subtype. No cells positive for CK20 or a-SMA were found in any AcCCs. Conclusions We demonstrated that the microcystic, follicular and papillary-cystic subtypes of AcCC exhibit features of ductal luminal cells with expression of CK7 and CK19, suggesting their ductal origination. By contrast, the solid subtype might originate from different cells with no ductal CK expression.

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