Taking the Heat Out of Organ Donation  

Oleh:

Jochmans, Ina ; Watson, Christopher J.E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 373 no. 05 (Jul. 2015), page 477-478.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The results of transplantation vary, depending on the quality of the organ and the nature of the donor. In 2012 in the United States, 73% of kidneys from deceased organ donors, as compared with 84% of kidneys from living donors, had been functioning for 5 years.1 One explanation for the superior results of living-donor kidney transplantation is the avoidance of the catastrophic physiological changes that accompany brain death in the deceased organ donor. Brain death has complex and widespread consequences that affect all organs. The autonomic reflex response to increasing intracranial pressure includes the release of massive quantities of catecholamines; this release causes peripheral vasospasm and reduced organ perfusion. In the process of brain death, hemodynamic instability worsens, with loss of sympathetic vascular tone and hypovolemia as a consequence of diabetes insipidus.

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