Nitroglycerin and Nitric Oxide — A Rondo of Themes in Cardiovascular Therapeutics  

Oleh:

Steinhorn, Benjamin S. ; Loscalzo, Joseph

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 373 no. 03 (Jul. 2015), page 277-280.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The rondo is a musical form in which a single recurrent theme alternates with different melodic motifs that are each distinct from one another. The recurrent theme is typically repeated multiple times, providing both the overall unity for the musical movement and a familiar musical destination to which the piece returns after the presentation of distinct interspersed themes. The parallels between the rondo form and the cyclic temporal pattern of experimental therapeutics are uncanny. Clinical observation is a recurring theme in drug development, in which the effects of treatment observed in patients may suggest novel therapeutic indications (or unanticipated side effects) that lead to the identification of new molecular targets and pathways. These observations in patients are typically interspersed with increasingly sophisticated analyses in novel experimental models, yielding a kind of “drug-development rondo.” The rondo being reviewed in this article takes place in the key of E — for endothelium. The drug in question is nitroglycerin, and its major active principal is nitric oxide, a gaseous molecule made in the vascular endothelium (and in other tissues) that is essential for vascular homeostasis.

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