Causality and Chance in the Development of Cancer  

Oleh:

Luzzatto, Lucio ; Pandolfi, Pier Paolo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 373 no. 01 (Jul. 2015), page 84-88.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The notion that, in addition to heredity (HER) and the environment (ENV), chance (C) is also a factor in oncogenesis is not new.1,2 However, it has received new impetus from the recent work by Tomasetti and Vogelstein,3 who reported a strong correlation between the frequency of tumors of individual organs or tissue types and the estimated number of stem-cell divisions in those organs or tissues. Thus, the wide variation between common tumors (e.g., colorectal cancer, which will develop in nearly 1 in 20 persons) and very rare tumors (e.g., osteosarcoma, which will develop in fewer than 1 in 10,000 persons) could be explained in large part by how many stem-cell divisions — each of which entails the risk of random mutations — have accumulated by a certain age or over a lifetime. This work has had resounding echoes in the general press, and some journalists have conveyed the misleading take-home message that the cause of cancer is not lifestyle but, rather, bad luck. Here we discuss briefly how chance, heredity, and the environment overlap and interact.

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