Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve: a case-control study  

Oleh:

Ferrero, Simone ; Scala, Carolina ; Racca, Annalisa ; Calanni, Luana ; Venturini, Pier Luigi ; Maggiore, Umberto Leone Roberti

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 05 (May 2015), page 1236–1243 .
Topik: AMH; antral follicle count; endometriosis; laparoscopy; ovarian reserve

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective To investigate the impact on ovarian reserve of second laparoscopic surgery for recurrent unilateral endometriomas. Design Case-control study. Setting University teaching hospital. Patient(s) This study included patients who underwent stripping of endometriomas (diameter =4 cm) and were followed-up at our institution. Case subjects had second surgery for recurrent unilateral endometriomas (n = 18); control subjects had no recurrence and no second surgery (n = 18). Intervention(s) This case-control study was based on a retrospective analysis of a prospectively collected database including patients who underwent surgery for endometriomas at our institution. Main Outcome Measure(s) The primary outcome of the study was to assess the changes in antimüllerian hormone (AMH) levels in each study group and between the two study groups. The secondary outcomes of the study were to assess the changes in basal FSH, antral follicle count (AFC), and ovarian volume in each study group and between the two study groups. Result(s) In both study groups, primary surgery decreased AMH, increased basal FSH, and decreased the AFC of the operated ovary. Before second surgery, case subjects had AMH, basal FSH, and AFC similar to control subjects. After second surgery, case subjects had lower AMH, higher basal FSH, and lower AFC of the affected ovary than before surgery; the volume of the operated ovary was lower than that of the contralateral ovary. Conclusion(s) The laparoscopic stripping of recurrent ovarian endometriomas is associated with a high risk of ovarian reserve damage and ovarian failure.

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