Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study  

Oleh:

Cherbuin, Nicolas ; Sargent-Cox, Kerry ; Easteal, Simon ; Sachdev, Perminder ; Anstey, Kaarin J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Geriatric Psychiatry (keterangan: ada di ClinicalKey) vol. 23 no. 05 (May 2015), page 446–455 .
Topik: Cognitive decline; longitudinal; APOE e4; MRI

Ketersediaan

Perpustakaan FK Nomor Panggil: A35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Objective To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. Methods Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60–64 years free from dementia, mild cognitive impairment, and other neurological disorders. Results SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. Conclusion Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.

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