Post–Glucose Load Plasma a-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study  

Oleh:

Maessen, Dionne E. ; Hanssen, Nordin M. ; Scheijen, Jean L. ; Kallen, Carla J. van der ; Greevenbroek, Marleen M. J. van

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 38 no. 05 (May 2015), page 913-920 .

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Perpustakaan FK Nomor Panggil: D05.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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OBJECTIVE There is increasing evidence that postprandial glucose excursions play an important role in the development of vascular complications. The underlying mechanism is unknown, but glucose-derived formation of reactive a-dicarbonyl compounds may explain why acute hyperglycemia leads to increased risk for diabetes complications. In the current study, we investigated whether a-dicarbonyls are increased after a glucose load in individuals without or with impaired glucose metabolism (IGM) and type 2 diabetes. RESEARCH DESIGN AND METHODS Cross-sectional, linear analyses were performed in the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM [n = 574, 61% men, 60 years old]) study. Individuals with normal glucose metabolism (n = 279), IGM (n = 120), and type 2 diabetes (n = 92) who had complete data on an oral glucose tolerance test (OGTT) and were not on insulin treatment were included in the study population. Plasma a-dicarbonyl (methylglyoxal [MGO], glyoxal [GO], and 3-deoxyglucosone [3-DG]) levels were measured in the fasting state and in samples of the OGTT by ultra-performance liquid chromatography–tandem mass spectrometry. RESULTS The presence of both IGM and type 2 diabetes was significantly associated with higher a-dicarbonyl incremental areas under the curve (iAUCs), as calculated from the OGTT (for IGM, MGO ß = 0.190 [95% CI 0.106–0.274], GO ß = 0.287 [95% CI 0.172–0.401], and 3-DG ß = 0.285 [95% CI 0.221–0.349]; for type 2 diabetes, MGO ß = 0.293 [95% CI 0.180–0.405], GO ß = 0.536 [95% CI 0.382–0.689], and 3-DG ß = 0.542 [95% CI 0.456–0.628]). Adjustment for glucose iAUC attenuated these associations. iAUCs of the a-dicarbonyls correlated highly with glucose iAUC but not with fasting glucose levels or HbA1c. CONCLUSIONS The increased levels of a-dicarbonyls during an OGTT in individuals with IGM and type 2 diabetes underline the potential importance of a-dicarbonyl stress as a candidate to explain the increased risk of diabetes complications in individuals with postprandial hyperglycemia.

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