Mutation-Specific T Cells for Immunotherapy of Gliomas  

Oleh:

Melief, Cornelis J.M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 372 no. 20 (Dobel) (May 2015), page 1956-1958.

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Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: 1

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Isi artikel

Cancers arise as a result of mutations that cause unbridled growth by deregulation of the normal cell cycle. A case in point is grade II or III gliomas, the large majority of which express a single mutation in the gene encoding isocitrate dehydrogenase 1 (IDH1). This substitution mutation (R132H) is considered to be a root cause of the initiation of these tumors.

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