Risk of subsequent cutaneous squamous cell carcinoma in patients with melanoma  

Oleh:

Asgari, Maryam M. ; Warton, E. Margaret ; Quesenberry, Charles P. ; Koralek, Daniel O. ; Taylor, Michael

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 71 no. 03 (Sep. 2014), page 521–528 .
Topik: epidemiology; incidence; melanoma; risk factors; skin cancer; squamous cell carcinoma

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background Patients with melanoma are at increased risk for cutaneous squamous cell carcinomas (SCCs). Objective We sought to examine the incidence of subsequent SCC among melanoma survivors and the impact of patient and melanoma characteristics on SCC risk. Methods Kaiser Permanente Northern California members given the diagnosis of melanoma from 2000 to 2005 (n = 6378) were followed up through 2009 for a pathology-confirmed SCC. Cox models were used to estimate SCC risk. Results The crude SCC incidence rate was 2.41 per 100 person-years, and was higher among males and older subjects. In adjusted models stratified by age, SCC risk was higher among males (hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.22-1.67), those with history of nonmelanoma skin cancer (HR 2.56, 95% CI 2.19-2.98), and those with higher tumor sequence numbers (HR 1.35, 95% CI 1.01-1.80). SCC risk was lower among non-Hispanic whites (HR 0.39, 95% CI 0.17-0.86). Limitations SCC risk was not examined among members without melanoma. Conclusions SCCs arise in approximately 12% of patients with melanoma over a 5-year period and are more common among males, whites, patients older than 60 years, those with prior reportable cancers, and those with history of nonmelanoma skin cancer. Clinicians should be vigilant for SCCs among these individuals at high risk, and counsel melanoma survivors about their increased risk for SCCs.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali