CD30+ cutaneous lymphoproliferative disorders with pseudocarcinomatous hyperplasia are associated with a T-helper-17 cytokine profile and infiltrating granulocytes  

Oleh:

Guitart, Joan ; Martinez-Escala, Maria Estela ; Deonizio, Janyana M.D. ; Gerami, Pedram

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 72 no. 03 (Mar. 2015), page 508-515.
Topik: CD30+ cutaneous lymphoproliferative disorders; cytokine profile; granulocytes; pseudocarcinomatous hyperplasia; squamous cell carcinoma; T-helper-17/22

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Background The pathogenetic mechanism of CD30+ cutaneous lymphoproliferative disorders (CLPD) associated with pseudocarcinomatous hyperplasia (PCH) and granulocytic inflammation surrounding atypical CD30+ lymphocytes remains unclear. Objective We sought to characterize clinical and pathological findings of a cohort of patients with PCH associated with CD30+ CLPD and to analyze the cytokine profile of the atypical lymphocytes. Methods We retrospectively reviewed medical records and pathological material of CD30+ CLPD with PCH. Immunohistochemistry for T-helper (Th)17 cytokine profile was performed. Results In all, 25 patients with a median age of 52 years were included. The median follow-up was 3.7 years. Histologically, an infiltrating pattern of PCH was observed in 14 cases with a neutrophilic-rich infiltrate (P = .21), and epidermal pattern in 11 cases with eosinophil-rich infiltrate (P = .03). Th17 or Th22 cytokines were detected in tumor cells in 81% cases tested. Tumor cells expressed Th17 transcription factor retinoic acid receptor (ROR)-related orphan receptor gamma-2 in 2 of 7 samples tested and 1 was positive for aryl hydrocarbon receptor. Limitations This is a retrospective study of a small sample. Conclusions PCH in CD30+ CLPD is associated with Th17/Th22 cytokine expression in the atypical lymphocytes. Although these lesions commonly regress spontaneously and are associated with an indolent course, some cases develop a generalized process and tumor progression.

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