Genetic Moderation of Child Maltreatment Effects on Depression and Internalizing Symptoms by Serotonin Transporter Linked Polymorphic Region (5-Httlpr), Brain-Derived Neurotrophic Factor (BDNF), Norepinephrine Transporter (NET), and Corticotropin Releasing Hormone Receptor 1 (CRHR1) Genes in African American Children  

Oleh:

Cicchetti, Dante ; Rogosch, Fred A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 26 no. 4 (Nov. 2014), page 1219–1239.
Topik: child maltreatment; internalizing symptoms; Child depression; internalizing problems; brain-derived neurotrophic factor; BDNF;
Fulltext: S0954579414000984a_Ros.pdf (831.57KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Genetic moderation of the effects of child maltreatment on depression and internalizing symptoms was investigated in a sample of low-income maltreated and nonmaltreated African American children (N ¼ 1,096). Lifetime child maltreatment experiences were independently coded from Child Protective Services records and maternal report. Child depression and internalizing problems were assessed in the context of a summer research camp by self-report on the Children’s Depression Inventory and adult counselor report on the Teacher Report Form. DNA was obtained from buccal cell or saliva samples and genotyped for polymorphisms of the following genes: serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter, and corticotropin releasing hormone receptor 1. Analyses of covariance with age and gender as covariates were conducted, with maltreatment status and respective polymorphism as main effects and their GeneEnvironment (GE) interactions. Maltreatment consistently was associated with higher Children’s Depression Inventory and Teacher Report Form symptoms. The results for child self-report symptoms indicated a GE interaction for BDNF and maltreatment. In addition, BDNF and triallelic 5-HTTLPR interacted with child maltreatment in a GGE interaction. Analyses for counselor report of child anxiety/depression symptoms on the Teacher Report Form indicated moderation of child maltreatment effects by triallelic 5-HTTLPR. These effects were elaborated based on variation in developmental timing of maltreatment experiences. Norepinephrine transporter was found to further moderate the GE interaction of 5-HTTLPR and maltreatment status, revealing a GGE interaction. This GGE was extended by consideration of variation in maltreatment subtype experiences. Finally, GGE effects were observed for the co-action of BDNF and the corticotropin releasing hormone receptor 1 haplotype. The findings illustrate the variable influence of specific genotypes in GE interactions based on variation in maltreatment experiences and the importance of a multigenic approach for understanding influences on depression and internalizing symptoms among African American children.

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