Progesterone-to-follicle index is better correlated with in vitro fertilization cycle outcome than blood progesterone level  

Oleh:

Shufaro, Yoel ; Sapir, Onit ; Oron, Galia ; Haroush, Avi Ben

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 03 (Mar. 2015), page 669-674.
Topik: IVF; progesterone; follicle; progesterone-to-follicle index

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective To investigate the impact of late follicular phase progesterone (P) elevation in relation to ovarian response on cycle outcome. Design Cohort study. The progesterone-to-follicle index (PFI) was calculated by dividing the blood P by the number of follicles =14 mm. The clinical pregnancy rate was calculated against the range of PFI values and blood P levels. Setting In vitro fertilization unit. Patient(s) A heterogenous population undergoing IVF with pituitary suppression and gonadotropin stimulation resulting in 3–15 follicles =14 mm and blood P=10 nmol/L on hCG day and resulting in fresh embryo transfer. Intervention(s) None. Main Outcome Measure(s) Association of blood P and PFI with clinical pregnancy rate. Result(s) Data were retrieved for 8,649 IVF cycles in normal responders. The (reverse) odd ratios for pregnancy were 1.112 (95% confidence interval [CI], 1.077–1.165) for blood P and 4.104 (95% CI, 3.188–5.284) for the PFI. Elevated P levels were associated with a lower pregnancy rate only when they reached the >93rd percentile. The PFI was inversely and linearly related to the pregnancy rate for the whole range of values. Conclusion(s) A late increase in P level is detrimental if it is a consequence of increased P production per follicle (high PFI) but not if it is a consequence of additional follicular recruitment. The PFI enables clinicians to differentiate these conditions.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali