Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Likelihood of Having Depressive Symptoms among Japanese Workers  

Oleh:

Mizoue, Tetsuya ; Kochi, Takeshi ; Akter, Shamima ; Eguchi, Masafumi ; Kurotani, Kayo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 145 no. 03 (Mar. 2015), page 541-546 .
Topik: cross-sectional studies; depressive symptoms; Japanese; worker; 25-hydroxyvitamin D

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Accumulating evidence suggests a protective role of vitamin D against mood disorders; however, epidemiologic studies are scarce in working populations. Objective: We investigated cross-sectionally the association of serum vitamin D status and depressive symptoms among Japanese workers. Methods: Participants were 1786 employees (9% women), aged 19–69 y, who received health check-ups and participated in a nutrition and health survey. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured with the use of a competitive protein binding assay. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression was used to estimate ORs with adjustment for potential confounding variables including dietary factors. Results: Overall, 92% of study participants had suboptimal vitamin D status [25(OH)D <30 µg/L]. Depressive symptoms were inversely associated with 25(OH)D. Compared with those with a 25(OH)D concentration of <20 µg/L, multivariable-adjusted ORs (95% CIs) for depressive symptoms (CES-D scale score =16) were 0.75 (0.59, 0.95) and 0.66 (0.41, 1.06) for those with a 25(OH)D concentration of 20–29 µg/L and =30 µg/L, respectively (P-trend = 0.01). After further adjustment for leisure-time physical activity and shift work (factors closely related to photo-initiated vitamin D production), the OR (95% CI) for the highest category of 25(OH)D was 0.70 (0.43, 1.14). The association between 25(OH)D and depressive symptoms appears to be linear, according to restricted cubic spline regression. Conclusion: Results suggest that lower concentrations of circulating vitamin D are associated with increased likelihood of having depressive symptoms among apparently healthy workers.

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