Brain Activation During Silent Word Generation Evaluated with Functional MRI  

Oleh:

Friedman, Lee ; Kenny, John T. ; Wise, Alexandria L. ; Wu, Dee ; Stuve, Traci A. ; Miller, David A. ; Jesberger, John A. ; Lewin, Jonathan S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 64 no. 2 (1998), page 231-256.
Fulltext: 64_02_Friedman.pdf (975.24KB)

Isi artikel

This is a study of word generation during functional MRI (fMRI). Eleven normal healthy subjects were instructed to generate words covertly, (i.e., silently) that began with particular letters. Images were acquired on a conventional 1.5T scanner at three contiguous axial planes encompassing language-related areas of the temporal and frontal lobe. The data were analyzed at the level of a Talairach box, after individually fitting the proportional Talairach grid system to each slice. The main variable of interest was the number of activated pixels within a Talairach box. Boxes with a significant increase in the proportion of activated pixels were located in three regions of the left neocortex: (1) Brodmann areas 44 and 45 in the dorsolateral frontal cortex (Broca’s area), (2) areas 21 and 37 in the temporal cortex, (3) and the striate/extrastriate cortex (areas 17 & 18). The results are discussed in terms of a cognitive model of word generation and are compared, in detail, with the results of prior relevant imaging studies.

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