Impact of Offspring Death on Cognitive Health in Late Life: The Cache County Study  

Oleh:

Greene, Daylee ; Tschanz, JoAnn T. ; Smith, Ken R. ; Ostbye, Truls ; Corcoran, Chris

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Geriatric Psychiatry (keterangan: ada di ClinicalKey) vol. 22 no. 11 (Nov. 2014), page 1307-1315.
Topik: cognitive decline; psychosocial stress; apoE

Ketersediaan

Perpustakaan FK Nomor Panggil: A35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Objective Experiencing the death of a child is associated with negative short-term mental health consequences, but less is known about cognitive outcomes and whether such associations extend to late life. We tested the hypothesis that experiencing an offspring death (OD) is associated with an increased rate of cognitive decline in late life. Methods This population-based longitudinal study observed four cognitive statuses spaced 3–4 years apart, linked to an extensive database containing objective genealogic and vital statistics data. Home visits were conducted with 3,174 residents of a rural county in northern Utah, initially without dementia, aged 65–105. Cognitive status was measured with the Modified Mini-Mental State Exam at baseline and at 3-, 7-, and 10-year follow-ups. OD was obtained from the Utah Population Database, which contains statewide birth and death records. Results In linear mixed models, controlling for age, gender, education, and apolipoprotein E status, subjects who experienced OD while younger than age 31 years experienced a significantly faster rate of cognitive decline in late life, but only if they had an e4 allele. Reclassifying all OD (regardless of age) according to subsequent birth of another child, OD was only related to faster cognitive decline when there were no subsequent births. Conclusion Experiencing OD in early adulthood has a long-term association with cognitive functioning in late life, with a gene–environment interaction at the apolipoprotein E locus. Subsequent birth of another child attenuates this association.

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