Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes  

Oleh:

Morris, Andrew P ; Voight, Benjamin F ; Teslovich, Tanya M ; Ferreira, Teresa ; Segre, Ayellet V

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 44 no. 09 (Sep. 2012), page 981–990.

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

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