Word and letter string processing networks in schizophrenia: Evidence for anomalies and compensation  

Oleh:

Griego, Jacqueline A. ; Cortes, Carlos R. ; Nune, Sunitha ; Fisher, Joscelyn E. ; Tagamets, M.-A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 107 no. 2 (2008), page 158-166.
Topik: Schizophrenia and language; Lateralization; Lexical-semantic processing; Imaging; Effective connectivity; Modeling
Fulltext: 107_02_Griego.pdf (418.69KB)

Isi artikel

Imaging studies show that in normal language correlated activity between anterior and posterior brain regions increases as the linguistic and semantic content (i.e., from false fonts, letter strings, pseudo words, to words) of stimuli increase. In schizophrenia however, disrupted functional connectivity between frontal and posterior brain regions has been frequently reported and these disruptions may change the nature of language organization. We characterized basic linguistic operations in word and letter string processing in a region-of-interest network using structural equation modeling (SEM). Healthy volunteers and volunteers with schizophrenia performed an fMRI one-back matching task with real words and consonant letter strings. We hypothesized that left hemisphere network dysfunction in schizophrenia would be present during processes dealing with linguistic/semantic content. The modeling results suggest aberrant left hemisphere function in schizophrenia, even in tasks requiring minimal access to language. Alternative mechanisms included increases in right hemisphere involvement and increased top-down influence from frontal to posterior regions.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali