Bilateral brain regions associated with naming in older adults  

Oleh:

Obler, Loraine K. ; Rykhlevskaia, Elena ; Schnyer, David ; Clark-Cotton, Manuella R. ; Spiro, Avron III ; Hyun, JungMoon ; Kim, Dae-Shik ; Goral, Mira ; Albert, Martin L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 113 no. 3 (2010), page 113-123.
Topik: Naming; Aging; MRI; DTI; Bilaterality
Fulltext: 113_03_Obler.pdf (2.36MB)

Isi artikel

To determine structural brain correlates of naming abilities in older adults, we tested 24 individuals aged 56–79 on two confrontation-naming tests (the Boston Naming Test (BNT) and the Action Naming Test (ANT)), then collected from these individuals structural Magnetic-Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data. Overall, several regions showed that greater gray and white matter volume/ integrity measures were associated with better task performance. Left peri-Sylvian language regions and their right-hemisphere counterparts, plus left mid-frontal gyrus correlated with accuracy and/or negatively with response time (RT) on the naming tests. Fractional anisotropy maps derived from DTI showed robust positive correlations with ANT accuracy bilaterally in the temporal lobe and in right middle frontal lobe, as well as negative correlations with BNT RT, bilaterally, in the white matter within middle and inferior temporal lobes. We conclude that those older adults with relatively better naming skills can rely on right-hemisphere peri-Sylvian and mid-frontal regions and pathways, in conjunction with left-hemisphere peri-Sylvian and mid-frontal regions, to achieve their success.

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